Histamine intolerance and Atopic Eczema treatment

Last time I wrote about leaky gut, which affect almost everybody, who is suffering from Atopic Eczema. This time it will be no difference, so everybody with Atopic Eczema (Atopic Dermatitis) read carefully, topic is histamine intolerance.

First I will tell you my short story:

When I visited a doctor for a first time, he prescribed me corticosteroids and antihistamines. I was taking antihistamines daily for a long time. Sometimes skipped on them and see no difference. Then I have tried to use them 3 weeks and 3 weeks off. I noticed no difference. I shared my experience with my doctor, she said that that its a long term treatment and I need to take them. I was skeptical, so I started to look for answers and found some studies:

in the first study, they were injecting histamine under the skin of patients with Atopic Eczema and healthy people. Healthy people noticed severe pruritus (itching) while people with AE noticed nothing. Their result was that histamines does not cause the problem of AE.

In the second study, patients were taking different types of antihistamines and the result was no better than placebo. They have found small improvements within old type of  antihistamines with sedative properties. But they said improvement was only because of sedative properties of antihistamines, not because of blocking histamine.

That moment I stopped using antihistamines immediately, the studies supported my findings that it’s not helping me at all.

I do not link to those two studies, because today I know, that they are wrong. I realized that not everything that I find on google scholar have to be true.

What the studies didn’t take into consideration was that there is a second source of histamine in your body.

Where does the histamine come from:

  1. your body creates histamine as a result of allergy
  2. you eat it in your daily food, nowadays food is full of histamine. It’s known as histamine intolerance.

What happens is, that your body is full of histamine and have to store it somewhere. And guess where does it store it? The biggest organ of your body is best suited for storing it – your skin. Sometimes it stores it in the lungs and thats where asthma come from.

So the antihistamines did’t worked because I have solved only one half of the problem. How to fix the second half of the problem? You should avoid eating histamine-rich foods (or don’t eat too much of them) and start using enzymes that helps you to get rid of histamine from food.

Here are some foods with histamine:

  • beer, wine and other fermented drinks (I think if you suffer from AE you should not drink alcohol at all)
  • canned tuna, salami, tofu
  • ketchup, mayonnaise, mustard

According to wikipedia atopic eczema page:

About one-third (33%) of atopic eczematics significantly improve their symptoms after following a histamine-free diet.

The enzyme that helps you with histamine intolerance is called diamine oxidase (DAO). There is a product that should be available worldwide called DAOSIN, here is a picture of mine:


Visit your allergist-immunologists to test you for histamine intolerance. Only a few doctors does this tests, so if you are not lucky, try antihistamines with eliminating histamine-rich food (or taking DAOSIN). Histamine intolerance is basically not an allergy, but it has the same symptoms, because it doesn’t matter if your body produces histamine or you eat it.

If your histamine intolerance is mild, you can try using combination of vitamins C, B6 and copper, which will help you to produce your own diamine oxidase – DAO enzyme.

Take a minute and read few articles about histamine intolerance. You will find full list of foods containing histamine and some more details.

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